

Venous thromboembolism (VTE), defined as deep vein thrombosis, pulmonary embolism, or both, is common. It is important to note that most people with a history of or risk factors for blood clotting disorders CAN receive Janssen COVID-19 Vaccine. After 90 days, patients may be vaccinated with any FDA-authorized or approved COVID-19 vaccine. People with a history of an episode of an immune-mediated syndrome characterized by thrombosis and thrombocytopenia (e.g., heparin-induced thrombocytopenia) should be offered another FDA-authorized or approved COVID-19 vaccine (i.e., mRNA vaccine) if it has been 90 days or fewer since their illness resolved. You should screen patients for a history of or risk factor for a blood clotting disorder. Learn more about considerations for selecting which booster dose to receive. People who developed TTS after their initial Janssen vaccines should not receive a Janssen booster dose. These women should be made aware of the increased risk for TTS and the availability of mRNA COVID-19 vaccines for a booster dose. Thrombosis with thrombocytopenia syndrome (TTS): The group at highest risk for TTS is women ages 18–49 years.Guillain-Barre Syndrome: Based on data after receipt of a Janssen COVID-19 Vaccine primary dose, the group at the highest risk for GBS is men 50-64 years.There are currently no data comparing the risk for myocarditis after a booster dose of Pfizer-BioNTech COVID-19 Vaccine versus a booster dose of Moderna COVID-19 Vaccine. Accumulating evidence from multiple sources suggests a higher risk for myocarditis following primary vaccination with Moderna compared to Pfizer-BioNTech. Myocarditis and pericarditis: Based on data after receipt of an mRNA COVID-19 primary series, the group at the highest risk for myocarditis and pericarditis is males aged 12-29 years.The rare risks of serious adverse events after a homologous or heterologous booster dose are also expected to be similar to those experienced after a primary series.

The frequency and type of local and systemic symptoms after a booster dose are generally similar to those experienced after a primary series.
J BUDS TRIAL
Discuss the risks and benefits and which product may be most appropriate with individual patients.Ĭlinical trial data using homologous (the same) or heterologous (“mix and match”) boosters show that both increase immune response.
J BUDS SERIES
People 18 years of age and older who have completed a primary COVID-19 vaccine series with any FDA-approved or FDA-authorized product have the option to receive any of the FDA-approved or FDA-authorized COVID-19 booster products (Pfizer-BioNTech 12 years of age and older formulation ), Moderna or Janssen).
